P040 Protein tyrosine phosphate non receptor type 22 regulates muramyl-dipeptide induced effects in human monocytes
نویسندگان
چکیده
منابع مشابه
Muramyl dipeptide-induced adjuvant arthritis.
Muramyl dipeptide, N-acetylmuramyl-L-alanyl-D-isoglutamine, induced adjuvant arthritis in WKA rats when injected in a water-in-oil emulsion prepared with Freund incomplete adjuvant (Difco), but not when emulsified with Drackeol and Arlacel A.
متن کاملProtein Tyrosine Phosphatase Non-Receptor Type 22 Modulates NOD2-Induced Cytokine Release and Autophagy
BACKGROUND Variations within the gene locus encoding protein tyrosine phosphatase non-receptor type 22 (PTPN22) are associated with the risk to develop inflammatory bowel disease (IBD). PTPN22 is involved in the regulation of T- and B-cell receptor signaling, but although it is highly expressed in innate immune cells, its function in other signaling pathways is less clear. Here, we study whethe...
متن کاملMuramyl dipeptide
T robust expression of microbial pattern recognition receptors such as TLR4 and Nod2 in intestinal stem cells reflects an active communication dynamic between the host and the gut microbiota. A new study reveals that muramyl dipeptide, the bacterial cell wall peptidoglycan motif, activates Nod2 within crypt base columnar Lgr5positive stem cells and promotes their survival. Apart from the immedi...
متن کاملAltered expression of protein tyrosine phosphatase, non-receptor type 22 isoforms in systemic lupus erythematosus
INTRODUCTION A C-to-T single nucleotide polymorphism (SNP) located at position 1858 of human protein tyrosine phosphatase, non-receptor type 22 (PTPN22) complementary DNA (cDNA) is associated with an increased risk of systemic lupus erythematosus (SLE). How the overall activity of PTPN22 is regulated and how the expression of PTPN22 differs between healthy individuals and patients with lupus ar...
متن کاملSurface calreticulin mediates muramyl dipeptide-induced apoptosis in RK13 cells.
Calreticulin (CRT) is a binding protein for apoptotic N-acetylmuramyl-L-alanyl-D-isoglutamine (L,D-MDP) or peptidoglycan in RK(13) cells. CRT on RK(13) cell surface (srCRT) forms complex(es) with tumor necrosis factor receptor 1 (TNFR1) and TNFR-associated death domain (TRADD) protein of the cell membrane. CRT polyclonal or monoclonal antibody binding to RK(13) srCRT dose-dependently inhibited ...
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ژورنال
عنوان ژورنال: Journal of Crohn's and Colitis
سال: 2013
ISSN: 1873-9946
DOI: 10.1016/s1873-9946(13)60063-x